The Fortress of Humaitá (1854–68), known metaphorically as the Gibraltar of South America, was a Paraguayan military installation near the mouth of the River Paraguay. A strategic site without equal in the region, "a fortress the likes of which had never been seen in South America", it was "the key to Paraguay and the upper rivers". It played a crucial role in the deadliest conflict in the continent's history – the Paraguayan War – of which it was the principal theatre of operations.